Ex Parte VAN DEN BERG et al - Page 4




                Appeal No. 95-0083                                                                                                         
                Application 07/711,556                                                                                                     


                        On consideration of the record, we reverse the double patenting rejection of                                       
                claims 43, 45 through 49 and 52.  However, we affirm the double patenting rejection of                                     
                claims 54 and 56 through 58.  We reverse the rejection of claims 43, 45, 46, 49, 52, 54                                    
                and 56 through 58 under 35 U.S.C. § 103.                                                                                   

                                                       DOUBLE PATENTING                                                                    
                        In rejecting the appealed claims for obviousness-type double patenting, the                                        
                examiner refers to claims 1 and 6 through 12 of U.S. Patent No. 4,859,596.  In our                                         
                judgment, however, the examiner has not adequately explained  how claims 43, 45                                            
                through 49, and 52 in this application define merely an obvious variation of the                                           
                invention set forth in claims 1 and 6 through 12 of the '596 patent.  See In re Vogel 422                                  
                F.2d 438, 441, 164 USPQ 619, 622 (CCPA 1970).  Claims 43, 45 through 49 and 52                                             
                define a method for producing a polypeptide of interest in a Kluyveromyces host cell,                                      
                where the polypeptide of interest is expressed in and secreted by the host cell.  In view                                  
                of this limitation, that the polypeptide is secreted by the host cell, we find that the                                    
                examiner has not established a prima facie case of obviousness-type double patenting.                                      




                As correctly pointed out by the examiner, claims 1 and 6 through 12 of the '596 patent                                     
                define a transformed Kluyveromyces cell in essentially the same terms found in                                             
                appealed claims 54 and 56 through 58.  That, however, is not sufficient to support a                                       
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