Ex parte RILEY et al. - Page 2



                 Appeal No. 95-1083                                                                                                                     
                 Application No. 08/004,444                                                                                                             




                          Claims 1 and 7 are illustrative of the claims on appeal and are appended to this                                              
                 decision.                                                                                                                              
                          The references relied upon by the examiner are:                                                                               
                                               2                                                                                                        
                 Eiichi Kimura (Kimura)                                         59-193,824                 Nov. 2, 1984                                 
                 (Japanese Kokai Patent Application)                                                                                                    
                 Fujioka et al. (Fujioka), "The Effects of Size and Donor Atoms of Macrocyclic Polyamines                                               
                                    2+          2+                                                                                                      
                 Binding to Mg  and Ca ," Chemistry Letters, pp. 737-740 (1982).                                                                        
                 Kimura et al. (Kimura (O)), "Further Studies on Superoxide Dismutase Activities of                                                     
                 Macrocyclic Polyamine Complexes of Copper (II)," Biochimica et Biophysica Acta., Vol.                                                  
                 745, pp. 37-43 (1983).                                                                                                                 
                 Kimura et al. (Kimura (E)), "Superoxide Dismutase Activity of Macrocyclic Polyamine                                                    
                 Complexes," Biochimica et Biophysica Acta., Vol. 678, pp. 172-179 (1981).                                                              
                 Weiss et al. (Weiss), "Catalytic Efficacies of Agents That Dismutase Superoxide"                                                       
                 (Abstract CC110), Journal of Cell Biochemistry, Supplement 15C, 216 (1991).                                                            
                 Petkau, "Scientific Basis For the Clinical Use of Superoxide Dismutase," Cancer                                                        
                 Treatment Reviews, Vol. 13, pp. 17-44 (1986).                                                                                          
                 Fretland et al. (Fretland), "Superoxide Dismutase (SOD) Modulates Acetic Acid-Induced                                                  
                 Colitis in Rodents" (abstract), Gastroenterology, Vol. 100, p. A581, 1991, presented at the                                            
                 American Gastroenterology Association Meeting in May 1990.                                                                             


                                                            Grounds of Rejection                                                                        




                          2The examiner in his answer and appellant in his principal brief have referred to the                                         
                 Derwent Pub. Abstract of Kimura.  We refer, in our opinion, to a translation of this                                                   
                 reference prepared for the PTO by Diplomatic Language Services, Inc., in May 1999, a                                                   
                 copy of which is attached to this decision.                                                                                            
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