Ex parte RILEY et al. - Page 3




             Appeal No. 95-1083                                                                                      
             Application No. 08/004,444                                                                              
                    Claims 1-3, 6-8, and 12 stands rejected under 35 U.S.C. § 101, as lacking                        
             demonstrated utility.                                                                                   


                    Claims 1-3, 6-8, and 12 stands rejected under 35 U.S.C. § 112, first paragraph, as               
             being based on a non-enabling disclosure.                                                               
                    Claims 1-3, 6-8, and 12 stand rejected under 35 U.S.C. § 103.  As evidence of                    
             obviousness, the examiner relies upon Kimura, Fujioka, Kimura (O), Kimura (E), Weiss,                   
             Petkau, and Fretland.                                                                                   
                    We reverse.                                                                                      
                                                  BACKGROUND                                                         

                    The applicants' invention, as described at pages 2 and 40-41 of the specification,               
             is directed  to manganese (II) or manganese (III) complexes of nitrogen containing sixteen-             
             member macrocyclic ligands which catalyze the conversion of superoxide into oxygen and                  
             hydrogen peroxide and are characterized by their ability to mimic superoxide dismutase.                 
             These complexes are stated to be useful in the treatment of numerous inflammatory                       
             disease states and related disorders, including reperfusion injury due to ischemia,                     
             inflammatory bowel disease, rheumatoid arthritis, osteoarthritis, and hypertension.                     
                                                   Discussion:                                                       

                    The Rejection under 35 U.S.C. § 101 and 35 U.S.C. § 112, first paragraph                         
                           Our appellate reviewing court recently stated in Fujikawa v. Watanasin, 93                
             F.3d 1559, 1563, 39 USPQ2d 1895, 1898-99 (Fed. Cir. 1996):                                              

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