Ex parte RILEY et al. - Page 9




                 Appeal No. 95-1083                                                                                                                     
                 Application No. 08/004,444                                                                                                             
                 (Answer, page 6).   Weiss, Petkau and Fretland are relied on as teaching "that superoxide                                              
                 dismutase related compounds similar to those of the primary references are known in the                                                
                 art for treatment of inflammatory bowel diseases" (Answer, page 7).   The examiner                                                     
                 concludes (Answer, page 7):                                                                                                            
                                   One having ordinary skill in the art would have been motivated, absent                                               
                          evidence to the contrary, to employ the claimed compound in methods and                                                       
                          compositions for the treatment and/or prevention of                                                                           


                          inflammatory bowel disease since it is an inflammatory condition and since                                                    
                          substantially related compounds were known in the art for their superoxide                                                    
                          dismutase related activity, which activity was known to be useful in the                                                      
                          treatment of inflammatory bowel disease.                                                                                      
                          In rejecting claims under 35 U.S.C. § 103, the examiner bears the initial burden of                                           
                 presenting a prima facie case of obviousness.  In re Oetiker, 977 F.2d 1443, 1445, 24                                                  
                 USPQ2d 1443, 1444 (Fed. Cir. 1992).  Only if that burden is met, does the burden of                                                    
                 coming forward with evidence or argument shift to the applicant.   Id.  The burden is on the                                           
                 examiner to provide a reason, based on the prior art, or knowledge generally available in                                              
                 the art as to why it would have been obvious to one of ordinary skill in the art to arrive at the                                      
                 claimed invention.  Ashland Oil, Inc. v. Delta Resins & Refractories, Inc., 776 F.2d 281,                                              
                 297, n.24, 227 USPQ 657, 667, n.24 (Fed. Cir. 1985).  If the examiner fails to establish a                                             
                 prima facie case, the rejection is improper and will be overturned.  In re Fine, 837 F.2d                                              
                 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir.1988).                                                                                       



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