Ex parte PERGOLIZZI et al. - Page 21




          Appeal No. 95-3606                                                          
          Application 07/827,691                                                      
          c dGTP:dGTP mixture in methods for ascertaining whether an7                                                                          
          individual is a carrier for, or afflicted with Fragile X.  To               
          the contrary, c dGTP:dGTP mixtures are preferred where, as7                                                            
          here, the presence and size of the amplified nucleic acid is                
          to be detected and compared with known standards using                      
          techniques known in the art (Claim 41, para. c)).                           
               “The consistent criterion for determination of                         
          obviousness is whether the prior art would have suggested to                
          one of ordinary skill in the art that this process should be                
          carried out and would have a reasonable likelihood of success,              
          viewed in light                                                             
          of the prior art.”  In re Dow Chemical Co., 837 F.2d 469, 473,              
          5 USPQ2d 1529, 1531 (Fed. Cir. 1988).  With regard to method                
          of Claims 41, 10, 11, 15, 27, 6, 9, 34 and 35, the prior art                
          on its face reasonably provides persons having ordinary skill               
          in the art with neither the motivation to perform appellants’               
          method for reliably ascertaining whether an individual is a                 
          carrier for, or afflicted with fragile X nor a reasonable                   
          likelihood of success.        We need not further consider the              
          evidence to which appellants point in rebuttal, because we                  
          hold that the combined teachings of Kremer, Innis I and Innis               


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