Ex parte PERGOLIZZI et al. - Page 26




          Appeal No. 95-3606                                                          
          Application 07/827,691                                                      
               in or expectation from the prior art that the claimed . .              
          .                                                                           
               composition will have the same or a similar utility as                 
          one                                                                         
               newly discovered by applicant. . . . In particular, the                
               statement that a prima facie obviousness rejection is not              
               supported if no reference shows or suggests the newly                  
               discovered properties and results of a claimed . . .                   
               [composition] is not the law.                                          
                    . . . The art provided the motivation to make the                 
               claimed compositions in the expectation that they would                
               have similar properties.                                               
               Having determined that the subject matter of Claims 42                 
          and 29-33 would have been prima facie obvious to a person                   
          having ordinary skill in the art for sequencing of DNA with                 
          high GC content in view of the combined teachings of Kremer,                
          Innis I, and Innis II,  the burden to present evidence to the4                                                     
          contrary shifted to appellants.  In re Piasecki, 745 F.2d at                
          1472, 223 USPQ      at 788.  However, the evidence appellants               
          have submitted in rebuttal emphasizes the kit’s unexpected                  
          utility in methods for reliably “ascertaining whether an                    
          individual is a carrier for, or afflicted with Fragile X”                   
          (Claim 41).  We restate our holding that the kit appellants                 
          claim is not limited for use in the method of Claim 41.  See                

              4    The examiner cited Kremer, Fig. 3, p. 1713, for its               
          description to include labeled probes for Southern blot analysis            
          of molecular size in addition to sequence analysis (Sec. Suppl.             
          Ans., p. 3, first full para.).                                              
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