Appeal No. 95-4823
Application 07/856,012
DECISION ON APPEAL
This is an appeal under 35 U.S.C. § 134 from the final rejection of claims 11, 12,
14, 17, 19, 21, and 22, all the claims remaining in the application. Claims 11 and 14 are
illustrative of the subject matter on appeal and read as follows:
11. A method of treating animals of the mammalian species, including humans, for
the purpose of reducing intraocular pressure in the eye of the mammal, the method of
treatment comprising the steps of administering to the mammal an ophthalmic solution
which comprises as its active ingredient one or more gamma aminobutyric acid agonist
compounds and wherein the active ingredient is present in the range of approximately 0.1
to 5 per cent weight by volume.
14. A method of treating animals of the mammalian species, including humans, for
the purpose of reducing intraocular pressure in the eye of the mammal, the method of
treatment comprising the steps of administering to the mammal an ophthalmic
composition in the form of eye droplets which comprises as its active ingredient one or
more gamma aminobutyric acid agonist compounds selected from a group consisting of:
gamma aminobutyric acid (GABA),
5-(aminomethyl)-3(2H)-isoxazolone (muscimol),
4,5,6,7-tetrahydroisoxazolopyridin-3-ol (THIP) and a pharmaceutically acceptable
salt of 4,5,6,7-tetrahydroisoxazolopyridin-3-ol,
piperidine-4-sulfonic acid and a pharmaceutically acceptable salt of piperidine-4-
sulfonic acid,
3-(2H)-isothiazolone, 5-(aminomethyl) (thiomuscimol),
7-chloro-1-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazaepin-2-one
(flurazepam) and a pharmaceutically acceptable salt of 7-chloro-1-5-(2-fluorophenyl)-1,3-
dihydro-2H-1,4-benzodiazaepin-2-one, and
7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
(chlordiazepoxide) and a pahrmaceutically acceptable salt of 7-chloro-N-methyl-5-
phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide the concentration of the gamma
aminobutyric acid agonist in the eye droplets being in the range of approximately 0.1 to 5
per cent, weight by volume.
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