Ex parte WOLDEMUSSIE et al. - Page 11




              Appeal No. 95-4823                                                                                             
              Application 07/856,012                                                                                         



              required by claim 11 on appeal.  Thus, it is not readily apparent from this record whether                     
              the dosages of diazepam used in Pino Capote fall within or without the claimed range.                          
                      Upon return of the application,  the examiner should consider this relevant                            
              disclosure of Pino Capote and determine whether the dosages of diazepam used in the                            
              reference fall within or without the range required by claim 11 on appeal.  If a dosage used                   
              by Pino Capote falls within the range required by claim 11 on appeal, Pino Capote might                        
              be anticipatory of claim 11.  If the dosages used by Pino Capote all fall outside the range                    
              required by claim 11, the examiner should determine whether it would have been obvious                         
              to one of ordinary skill in the art to adjust the dosage to a value within the claimed range.  In              
              so doing, the examiner should take into account Pino Capote’s finding that "diazepam was                       
              found to reduce [intraocular pressure] in a dose-dependent manner (fig. 2)."                                   
                      We also take this opportunity to comment upon some of appellants’ arguments                            
              presented in regard to Pino Capote in the Appeal Brief.  Appellants argue at page 8 of the                     
              Appeal Brief that Pino Capote only discloses reduction of intraocular pressure in the                          
              experimental cats for up to 20 minutes.  Appellants believe that reducing intraocular                          
              pressure for only 20 minutes is of no practical significance.  We have two problems with                       
              appellants’ argument.  First, Pino Capote only measured intraocular pressure for 20                            
              minutes which appears to be the reason why values are only reported in that time frame.                        
              This does not mean that intraocular pressure was not reduced beyond 20 minutes.  It only                       

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