Ex parte WOLDEMUSSIE et al. - Page 10




              Appeal No. 95-4823                                                                                             
              Application 07/856,012                                                                                         



              5.  Appellants’ discussion of other references.                                                                
                      At pages 12-13 of the Appeal Brief, appellants discuss other references of record                      
              which they believe are relevant in determining the patentability of the claims on appeal.                      
              Once again, the examiner has ignored a substantative portion of the Appeal Brief.  This                        
              constitutes yet another error on the part of the examiner.  In re Hedges, supra.                               
                      The rejection is reversed.                                                                             


                                                        Other Issue                                                          
                      Notwithstanding our disposition of the examiner’s rejection, there are significant                     
              issues of patentability present in this record which have not been properly considered by                      
              the examiner.  We direct attention to Pino Capote.  This reference describes administering                     
              diazepam either intravenously or by eye drop into the conjunctival sac of cats in order to                     
              determine if diazepam will decrease intraocular pressure.  Diazepam is a GABA agonist                          
              according to the present invention.  See page 4, lines 27-28 of the supporting                                 
              specification.  Pino Capote reports that diazepam was found to significantly reduce                            
              intraocular pressure by either mode of administration.                                                         
                      In comparing the subject matter of claim 11 on appeal with the described procedure                     
              in Pino Capote, it is not clear whether the diazepam was present in the compositions used                      
              by Pino Capote "in the range of approximately 0.1 to 5 per cent weight by volume" as                           

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