Appeal No. 95-4823 Application 07/856,012 One skilled in the art would have been motivated to combine the teaching of the above references, since one relates to the claimed type compounds in lowering intraocular pressure and the other relates to the use of diazepam a well known GABA agonist for reducing intraocular pressure. The above references make clear that diazepam having GABA agonist activity has been previously used for lowering intraocular pressure. Such teaching reads on the generic claim which is directed to the use of a GABA agonist for the treatment of glaucoma. The specific amino butyric agonists are also rejected over the combination of the relied upon reference, since it would have been obvious to a person skilled in the art to substitute one GABA agonist for another. Thus, for the above reasons and in view of relied upon references, the claimed use does not patentably distinguish over the state of the art, and claims 11, 12, 14, 17, 19, 21 and 22 are properly rejected under 35 USC 103. First, while the statement of the rejection proposes to combine "the teaching [sic] of [Kastner and Pino Capote]” the examiner has not explained which portions of the references are to be combined and in what manner. As set forth in the Manual of Patent Examining Procedure (MPEP) § 706.02(j) (6th ed., no. 3, July 1997), in making a rejection under 35 U.S.C. § 103, the examiner should set forth . . . (1) the relevant teachings of the prior art relied upon, preferably with reference to the relevant column or page number(s) and line number(s) where appropriate, (2) the difference or differ- ences in the claim over the applied reference(s), (3) the proposed modification of the applied reference(s) necessary to arrive at the claimed subject matter, and (4) an explanation why such proposed modification would have been obvious to one of ordinary skill in the art at the time the invention was made. Failure of the examiner to identify the difference or differences in the claims over the applied references and clearly communicating the proposed modification of the applied 7Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 NextLast modified: November 3, 2007