Ex parte WOLDEMUSSIE et al. - Page 7




              Appeal No. 95-4823                                                                                             
              Application 07/856,012                                                                                         



                      One skilled in the art would have been motivated to combine the teaching                               
                      of the above references, since one relates to the claimed type compounds in                            
                      lowering intraocular pressure and the other relates to the use of diazepam a                           
                      well known GABA agonist for reducing intraocular pressure.  The above                                  
                      references make clear that diazepam having GABA agonist activity has                                   
                      been previously used for lowering intraocular pressure.  Such teaching reads                           
                      on the generic claim which is directed to the use of a GABA agonist for the                            
                      treatment of glaucoma.  The specific amino butyric agonists are also                                   
                      rejected over the combination of the relied upon reference, since it would                             
                      have been obvious to a person skilled in the art to substitute one GABA                                
                      agonist for another.  Thus, for the above reasons and in view of relied upon                           
                      references, the claimed use does not patentably distinguish over the state of                          
                      the art, and claims 11, 12, 14, 17, 19, 21 and 22 are properly rejected under                          
                      35 USC 103.                                                                                            
                      First, while the statement of the rejection proposes to combine "the teaching [sic] of                 
              [Kastner and Pino Capote]” the examiner has not explained which portions of the                                
              references are to be combined and in what manner.  As set forth in the Manual of Patent                        
              Examining Procedure (MPEP) § 706.02(j) (6th ed., no. 3, July 1997), in making a rejection                      
              under 35 U.S.C. § 103,                                                                                         
                      the examiner should set forth . . .  (1) the relevant teachings of the prior art                       
                      relied upon, preferably with reference to the relevant column or page                                  
                      number(s) and line number(s) where appropriate, (2) the difference or differ-                          
                      ences in the claim over the applied reference(s), (3) the proposed                                     
                      modification of the applied reference(s) necessary to arrive at the claimed                            
                      subject matter, and (4) an explanation why such proposed modification                                  
                      would have been obvious to one of ordinary skill in the art at the time the                            
                      invention was made.                                                                                    
              Failure of the examiner to identify the difference or differences in the claims over the                       
              applied references and clearly communicating the proposed modification of the applied                          

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