Ex parte FRIEDMAN et al. - Page 8




          Appeal No. 95-4914                                                          
          Application No. 08/036,116                                                  


          nanoparticles.  See de Vringer at page 5, lines 13-21.                      
          Accordingly, we agree with the examiner that a prima facie                  
          case of obviousness is established for the subject matter                   
          defined by the broader claims on appeal.                                    
               We also find that de Vringer fairly suggests the subject               
          matter of the separately argued dependent claims.  For                      
          example, appealed claim 2 specifies a mean droplet size range               
          of between about 0.1 and 0.3 microns (i.e., between 100 and                 
          300 nanometers) while de Vringer discloses a somewhat broader               
          droplet size range between 50 and 1000 nanometers(page 4, line              
          35) and exemplifies a composition having a mean particle size               
          droplet of 132 nanometers (page 6, line 12).  With respect to               
          the appealed claims 20 and 21, which call for a skin                        
          penetration enhancer component, we note that de Vringer also                
          contemplates the use of penetration enhancers.  See page 5,                 
          lines 25 and 26 of the reference.  With respect to appellants’              
          arguments that imply that de Vringer does not suggest                       
          application of the prior art compositions to treat skin                     
          disorders, for example, as specified in appealed claim 25, we               
          point out that de Vringer’s compositions are useful as anti-                
          psoriatics and anti-eczema agents.  See the reference at page               
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