Ex parte ALFANO et al. - Page 2




          Appeal No. 97-3292                                                          
          Application 08/522,827                                                      


          subcutaneous sample.  An understanding of the invention can be              


          derived from a reading of exemplary claim 14, a copy of which               
          appears in the APPENDIX to the brief (Paper No. 17).                        


               As evidence of obviousness, the examiner has applied the               
          documents listed below:                                                     
          Alfano et al             5,131,398                     Jul. 21,             
          1992                                                                        
          (Alfano)                                                                    
          Wilk                          5,246,424                     Sep.            
          21, 1993                                                                    
          Shipp                    5,263,937                     Nov. 23,             
          1993                                                                        
          Janes et al              5,280,788                     Jan. 25,             
          1994                                                                        
          (Janes)                                 (filed Feb. 26,                     
          1991)                                                                       

               The following rejection is before us for review.                       


               Claims 14 and 16 through 20 stand rejected under 35                    
          U.S.C.                                                                      
          § 103 as being unpatentable over Alfano in view of Janes and                
          Shipp or Wilk.                                                              



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