Ex parte NICHOLSON - Page 2



          Appeal No. 1996-2229                                                        
          Application 08/196,748                                                      






               The references relied on by the examiner are:                          
          Yoshimoto et al. (Yoshimoto)(SS), “Isolation and Characterization           
          of Leukotriene C  Synthetase of Rat Basophilic Leukemia Cells,”             
                          4                                                           
          80 Proc. Natl. Acad. Sci., USA, 8399-8403 (1985).                           
          Yoshimoto et al. (Yoshimoto)(RR), “Properties of Highly Purified            
          Leukotriene C  Synthase of Guinea Pig Lung,” 81 J. Clin. Invest.,           
                       4                                                              
          866-71 (1988).                                                              
          Söderström et al. (Söderström)(TT), “Leuktriene C  Synthase:                
                                                           4                          
          Characterization in Mouse Mastocytoma Cells, 187 Methods in                 
          Enzymology, 306-12 (1990).                                                  
          Söderström et al. (Söderström)(U), “On the Nature of Leukotriene            
          C  Synthase in Human Platelets,” 294 Archives of Biochemistry and           
           4                                                                          
          Biophysics, 70-74 (1992).                                                   

               In the Appeal Brief, page 6, appellant relies on the                   
          following                                                                   
          reference:                                                                  
          Nicholson et al. (Nicholson), “Purification of Human Leukotriene            
          C  Synthase from Dimethylsulfoxide-Differentiated U937 Cells,”              
           4                                                                          
          209 Eur. J. Biochem., 725-34 (1992).                                        

               Claims 1 through 4 stand rejected under 35 U.S.C. § 112,               
          second paragraph, as indefinite.  Claims 1 through 4 also stand             
          rejected under 35 U.S.C. § 102 as anticipated by or, in the                 
          alternative, under 35 U.S.C. § 103 as unpatentable over                     



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