Ex parte NICHOLSON - Page 4



          Appeal No. 1996-2229                                                        
          Application 08/196,748                                                      



          drawn to purified LTC  synthase where the enzyme is purified to             
                               4                                                      
          homogeneity.  See particularly, these passages in the                       
          specification: Abstract of the Disclosure; Summary of the                   
          Invention, page 2, lines 13-16; and Example 1 at page 21, where a           
          single polypeptide of 18 kDa is obtained on silver stained SDS-             
          polyacrylamide denaturing gels.                                             
          In our judgment, claim 1, read in light of the application                  
          disclosure, reasonably apprises those skilled in the art that               
          appellant's invention is LTC  synthase purified to homogeneity              
                                      4                                               
          and substantially free of other contaminants.  That is the                  
          broadest reasonable interpretation of the claim language “LTC4              
          synthase, in substantially free form, having a molecular weight             
          of 18 kDa as determined on silver stained SDS-polyacrylamide                
          denaturing gel.”                                                            


                           35 U.S.C. § 112, SECOND PARAGRAPH                          
               Claims 1 through 4 stand rejected under 35 U.S.C. § 112,               
          second paragraph, as indefinite in view of the phrase “in                   
          substantially free form.”  This rejection is reversed.  For the             
          reasons already discussed, we conclude that appellant's claims              
          are drawn to LTC  synthase purified to homogeneity, having a                
                          4                                                           
          molecular weight of                                                         

                                            4                                         




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