Ex parte NICHOLSON - Page 7



          Appeal No. 1996-2229                                                        
          Application 08/196,748                                                      



          appropriate Office action setting forth the basis for that                  
          position.  In so doing, the examiner should designate “as nearly            
          as practicable” the particular part or passage of each prior art            
          reference relied on.                                                        
          37 CFR § 1.104(c)(2).  Further, the examiner should provide a               
          substantive response to appellant's reliance on Nicholson as                
          evidence of non-obviousness.  See the Appeal Brief, page 6.                 
          Further, in reevaluating the patentability of claims 1 through 4            
          on prior art grounds, the examiner should consider the proper               
          interpretation of those claims as discussed in the first section            
          of this opinion.                                                            
               We remand this application to the examiner to reevaluate the           
          patentability of claims 1 through 4 in light of the foregoing               
          discussion.  On the surface, it would appear the Yoshimoto (RR)             
          constitutes the closest prior art in this case.  This follows               
          from the examiner's argument that Yoshimoto (RR) describes a 91-            
          fold purification of LTC  synthase (Examiner's Answer, page 7)              
                                  4                                                   
          and appellant's similar description of that reference in the                
          Appeal Brief, page 5.  Therefore, on return of this application,            
          we recommend that the examiner pay particular attention to                  
          Yoshimoto (RR).  The examiner should explain why the subject                
          matter sought to patented in claims 1 through 4, properly                   

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