Ex parte MERETE - Page 3




              Appeal No. 97-1843                                                                                         
              Application 08/092,574                                                                                     



              Great Britain Patent Application (Kogyo)    2,007,091 A     May 16, 1979                                   
              Hansen, S. (Hansen), “Intraocular penetration of fusidic acid with topical Fucithalmic®,”                  
              European Journal of Drug Metabolism and Pharmacokinetics, Vol. 10, No. 4, pp 329-331                       
              (1985)                                                                                                     
              MEDLINE abstract AN 86164451 of Hansen                                                                     
                     Claims 6 through 9 stand rejected under 35 U.S.C. § 103.  The examiner relies                       
              upon Godtfredsen and Schoenwald as evidence of obviousness.  We reverse the                                
              rejection.  In addition, we make a new ground of rejection under 37 CFR § 1.196(b) and                     
              raise other issues for the examiner and appellant to consider.                                             
                                                     DISCUSSION                                                          
                     Claim 7 is directed to a method of treating an eye infection that comprises the step                
              of applying an effective amount of an ophthalmic gel composition as an eye drop into the                   
              fornix inferior of the eye (an arched shaped roof (or roof portion) of the eye).  The                      
              ophthalmic gel composition, requires, inter alia, a viscosity of from 10 to about 20,000 cps               
              at 25EC.                                                                                                   
                     To establish prima facie obviousness of claimed subject matter, all the claim                       
              limitations must be taught or suggested by the prior art.   See In re Royka, 490  F.2d 981,                
              984, 180 USPQ 580, 582  (CCPA 1974).  The examiner has not pointed to any specific                         
              reason, suggestion, or motivation stemming from the prior art which would have led a                       



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