Ex parte MERETE - Page 13




              Appeal No. 97-1843                                                                                        
              Application 08/092,574                                                                                    



              (10)  Godtfredsen also discloses that fusidic acid and salts thereof  may be mixed                        
              with a liquid or a solid pharmaceutical carrier, and may be used in any conventional form.                
              Godtfredsen, column 6, lines 18-46.                                                                       
                     (11) Godtfredsen discloses that fusidic acid and salts thereof can be isolated in                  
              particulate form.  Godtfredsen, column 2, lines 16-21; column 5, lines 41-46.  Godtfredsen                
              exemplifies a topical ointment in which the sodium salt of fusidic acid is used in particulate            
              form.  Godtfredsen, column 6, lines 56-74.                                                                
                     In reviewing the above facts, the examiner should determine whether the subject                    
              matter recited in claims 6 through 9 as a whole would have been obvious at the time the                   
              invention was made to a person having ordinary skill in the art to which this subject matter              
              pertains over the combined disclosures of Kogyo and Godtfredsen.   In determining the                     
              patentability of claims 6 through 9,  the examiner should also consider the facts presented               
              in the Jensen Rule 132 Declaration.   Patentability is determined on the totality of the                  
              record, by a preponderance of evidence with due consideration to persuasiveness of                        
              argument.   See Oetiker, supra.    “If the appellant comes forward with reasonable rebuttal,              
              whether buttressed by experiment, prior art references, or argument, the entire merits of                 
              the matter are to be weighed.”   Hedges, supra.                                                           
                    IV.  From a review of the application file, it is noted that priority under 35 U.S.C. §            
              119 is claimed to British patent application 8500310 filed Jan. 7, 1985.  See the substitute              

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