Ex parte MERETE - Page 4




              Appeal No. 97-1843                                                                                         
              Application 08/092,574                                                                                     



              person having ordinary skill to a gel composition having a viscosity of from 10 to                         
              about 20,000 cps at 25EC.                                                                                  
                     Godtfredsen discloses that fusidic acid is a well-known antibiotic, which is effective              
              against a number of pathogenic microorganisms.  See Godtfredsen, Table 1.                                  
              Godtfredsen also discloses that fusidic acid may be mixed with a liquid or a solid                         
              pharmaceutical carrier, and may be used in any conventional form.  Godtfredsen, column                     
              6, lines 18-46.  However, Godtfredsen does not disclose or suggest that fusidic acid can                   
              be used in a gel composition that has a viscosity of from 10 to about 20,000 cps at 25EC.                  
                     Schoenwald discloses that CARBOPOL polymers can be used as carriers for                             
              various antibiotics when the antibiotics are to be topically used.  Schoenwald discloses                   
              that the use of such polymers with an antibiotic results in long-acting well-retained gel                  
              preparations which are especially suited for ophthalmic applications.  Schoenwald,                         
              column 1, lines 59-62; column. 2, lines 57-59.  Schoenwald discloses that such gel                         
              preparations have a viscosity of from about 40,000 to about 300,000 cps at 20 rpm                          
              (spindle 7) at 25EC generated by an RVT Brookfield Viscometer.   Schoenwald, column 2,                     
              lines 21-26.   Schoenwald does not disclose or suggest gel preparations having a                           
              viscosity of from 10 to about 20,000 cps as recited in claim 7.                                            
                     Furthermore, the examiner has failed to consider the Jørgen Roed Jensen Rule 132                    
              Declaration, Paper No. 25, filed Jan. 6, 1993, which is discussed by appellant to support                  

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