Ex parte KOSLEY JR. et al. - Page 2




          Appeal No. 1997-2188                                                        
          Application 08/137,440                                                      
          consideration as claims to the previously non-elected                       
          invention, 37 C.F.R.  1.142(b), and, accordingly, form no                  
          issue in this appeal.                                                       




                                    THE INVENTION                                     
               The appealed subject matter is directed to a genus of                  
          compounds which may be broadly characterized as galanthamine                
          derivatives, pharmaceutical compositions comprising a                       
          pharmaceutically acceptable carrier and an                                  
          acetylcholinesterase (AChE) inhibiting amount of the                        
          galanthamine derivative, methods of treating memory                         
          dysfunction characterized by decreased cholinergic function by              
          administering to a mammal an AChE inhibiting amount of the                  
          galanthamine derivative and methods of treating memory                      
          dysfunction characterized by decreased cholinergic function by              
          administering to a mammal an AChE inhibiting amount of the                  
          galanthamine derivative which metabolizes in situ to form 6-O-              
          demethylgalanthamine.  According to appellants, the claimed                 
          family of galanthamine derivatives possesses the ability to                 
          inhibit the enzyme AChE.  The enzyme AChE lowers acetylcholine              
          levels in the brain.  Inhibition of AChE therefore increase                 
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