Ex parte ICHITSUKA et al, - Page 4




          Appeal No. 1997-3813                                                        
          Application No. 08/371,205                                                  


          invention is described, either explicitly or inherently, in                 
          Takata.  Hence, it is our determination that the examiner has               
          not carried the initial burden of establishing a prima facie                
          case of unpatentability.  In re Oetiker, 977 F.2d 1443, 1445,               
          24 USPQ2d 1443, 1444 (Fed. Cir. 1992).                                      
               Specifically, we find that Takata describes a sintered                 
          microporous hydroxyapatite body of an open pore structure                   
          having a porosity in the range from 20% to 50%, of which the                
          micropores have a distribution of diameters in the range from               
          0.01 to 0.1 mm (10 to 100 Fm).  (Column 2, lines 34-40.)  The               
          sintered microporous hydroxyapatite body is said to be useful               
          as a filling in a bone cavity or as a prosthetic member.                    
          (Column 2, lines 29-33.)  Takata further teaches:                           
               The microporous hydroxyapatite body as mentioned                       
               above can be prepared, taking the granular form                        
               suitable for filling use as a product form, for                        
               example, by admixing 100 parts by weight of a                          
               powdery hydroxyapatite having a particle size                          
               distribution as fine as possible or in the range                       
               from 0.1 to 10 Fm with from 25 to 100 parts by                         
               weight of a thermally decomposable powdery material                    
               having a particle diameter in the range from 0.01 to                   
               0.1 mm [10 to 100 Fm] and granulating the powdery                      
               blend into granules having a particle diameter in                      
               the range from 0.1 to 3 mm [100 to 3000 Fm] by a                       
               known method, optionally, with admixture of a                          
               suitable binder such as an aqueous solution of                         
               polyvinyl alcohol followed by calcination and                          
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