Ex Parte LIGLER et al - Page 6


                 Appeal No.  1999-1384                                                                                 
                 Application No.  08/583,912                                                                           
                        Accordingly we reverse the rejection of claim 25 under 35 U.S.C. § 112,                        
                 second paragraph.                                                                                     
                 THE REJECTION UNDER 35 U.S.C. § 103:                                                                  
                        The initial burden of presenting a prima facie case of obviousness rests                       
                 on the examiner.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444                            
                 (Fed. Cir. 1992).  In meeting this burden, we note that it is well-established that                   
                 before a conclusion of obviousness may be made based on a combination of                              
                 references, there must have been a reason, suggestion or motivation to lead an                        
                 inventor to combine those references. Pro-Mold and Tool Co. v. Great Lakes                            
                 Plastics Inc., 75 F.3d 1568, 1573, 37 USPQ2d 1626, 1629 (Fed. Cir. 1996).                             
                 Furthermore, as set forth in Ecolochem Inc. v. Southern California Edison, 227,                       
                 F.3d 1361, 1375, 56 USPQ2d 1065, 1075 (Fed. Cir. 2000) the:                                           
                        “[S]uggestion to combine may be found in explicit or implicit                                  
                        teachings within the references themselves, from the ordinary                                  
                        knowledge of those skilled in the art, or from the nature of the                               
                        problem to be solved.” … However, there still must be evidence                                 
                        that “a skilled artisan, confronted with the same problems as the                              
                        inventor and with no knowledge of the claimed invention, would                                 
                        select the elements from the cited prior art references for                                    
                        combination in the manner claimed.” … “[A] rejection cannot be                                 
                        predicated on the mere identification … of individual components of                            
                        claimed limitations.  Rather particular findings must be made as to                            
                        the reason the skilled artisan, with no knowledge of the claimed                               
                        invention, would have selected these components for combination                                
                        in the manner claimed.”….  [Citations omitted].                                                
                        According to the examiner (Answer, page 4) Ligler “teach a device and                          
                 method for a displacement assay essentially as claimed….”  In addition, the                           
                 examiner finds (Answer, page 5) that “[l]imitations regarding … optimization of                       




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