VISSER et al v. HOFVANDER et al - Page 101




          Interference 103,579                                                        
          only that the subject matter Hofvander claims would not have been           
          prima facie obvious under 35 U.S.C. § 103 in view of the combined           
          teachings of Hergersberg and van der Leij, but that the subject             
          matter Visser claims would not have been prima facie obvious                
          under 35 U.S.C. § 103 in view of the subject matter Hofvander’s             
          claims, the combined teachings of Hergersberg and van der Leij,             
          or a combination of Hofvander’s claims and the teachings of                 
          Hergersberg and van der Leij, i.e., Hofvander’s claims designated           
          as corresponding to the count and Visser’s claims designated as             
          corresponding to the count are patentable over Hergersberg’s                
          teaching and there is in this case no interference-in-fact.                 
               To the contrary, Hofvander argues that the following “facts”           
          establish a reasonable level of predictability for the particular           
          antisense technology to which the parties claims designated as              
          corresponding to the count relate:                                          
                    The important thing about antisense technology                    
               is . . . that the DNA fragment (segment) used is                       
               homologous to the gene that is to be inhibited and                     
               functions to inhibit the expression of that same gene.                 
               Full length or not is of no importance.                                
          (HB 27 (citing HB 6, Fact 6));                                              
               [A]s shown by Hofvander, both fragments of and the full                
               length GBSS gene will result in inhibition of amylose                  
               formation and thus production of essentially amylose-free              
               amylopectin.                                                           
          (HB 27-27, bridging para.);                                                 
               By reference to the Interference Initial Memorandum,                   
               it can be seen that the Examiner considered the use of                 
                                        -101-                                         





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