Appeal No. 2001-0246 Application No. 08/921,103 and the junction solution flow on the other surface of the junction which indicates a flowing junction solution (answer, pages 7 and 8). In rejecting claims under 35 U.S.C. § 103, the examiner bears the initial burden of presenting a prima facie case of obviousness. See In re Rijckaert, 9 F.3d 1531, 1532, 28 USPQ2d 1955, 1956 (Fed. Cir. 1993). A prima facie case of obviousness is established by presenting evidence that the reference teachings would appear to be sufficient for one of ordinary skill in the relevant art having the references before him to make the proposed combination or other modification. See In re Lintner, 458 F.2d 1013, 1016, 173 USPQ 560, 562 (CCPA 1972). After reviewing Europe, we agree with the Examiner that the disclosed porous salt bridge has one surface exposed to the flow of the sample fluid and the other surface exposed to the flow of a reference fluid (col. 1, lines 49-53). As depicted in Figure 2, Europe discloses flow cell 10 in which the sample fluid passes through flow path 13 on one side of porous bridge element 17 (col. 2, lines 45-48) and reference fluid passes through tubes 15 and 16 into chamber 21 on the other side of the porous bridge element (col. 3, lines 4-11). As also pointed out by Appellants (brief, page 14), Europe further discloses that the 6Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 NextLast modified: November 3, 2007