Ex Parte CHAN et al - Page 6




          Appeal No.  2001-0246                                                       
          Application No.  08/921,103                                                 

          and the junction solution flow on the other surface of the                  
          junction which indicates a flowing junction solution (answer,               
          pages 7 and 8).                                                             
               In rejecting claims under 35 U.S.C. § 103, the examiner                
          bears the initial burden of presenting a prima facie case of                
          obviousness.  See In re Rijckaert, 9 F.3d 1531, 1532, 28 USPQ2d             
          1955, 1956 (Fed. Cir. 1993).  A prima facie case of obviousness             
          is established by presenting evidence that the reference                    
          teachings would appear to be sufficient for one of ordinary                 
          skill in the relevant art having the references before him to               
          make the proposed combination or other modification.  See In re             
          Lintner, 458 F.2d 1013, 1016, 173 USPQ 560, 562 (CCPA 1972).                
               After reviewing Europe, we agree with the Examiner that the            
          disclosed porous salt bridge has one surface exposed to the flow            
          of the sample fluid and the other surface exposed to the flow of            
          a reference fluid  (col. 1, lines 49-53).  As depicted in Figure            
          2, Europe discloses flow cell 10 in which the sample fluid                  
          passes through flow path 13 on one side of porous bridge element            
          17 (col. 2, lines 45-48) and reference fluid passes through                 
          tubes 15 and 16 into chamber 21 on the other side of the porous             
          bridge element (col. 3, lines 4-11).  As also pointed out by                
          Appellants (brief, page 14), Europe further discloses that the              

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