Appeal No. 2001-0246 Application No. 08/921,103 which the reference liquid contacts the sample liquid and the possibility of cross contamination is increased. Therefore, as the Examiner asserts, one of ordinary skill in the art would have used the recirculating layout of Hofmeier for the reference liquid of Europe which includes a constraint junction wherein contamination of the reference fluid is less likely. Based on our findings related to the applied prior art and the analysis made above, we find that the Examiner has established a prima facie case of obviousness. Therefore, the 35 U.S.C. § 103 rejection of claim 47 over Europe and Hofmeier and of claim 49 over Europe, Hofmeier and Covington is sustained. 11Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 NextLast modified: November 3, 2007