Ex Parte GRANADOS et al - Page 14


                   Appeal No. 2002-2030                                                                 Page 14                       
                   Application No. 09/294,663                                                                                         

                   recombinant DNA is an obvious form of DNA, since the combination of a gene                                         
                   with other DNA sequences (promoters, plasmid vector sequences, etc.) with                                          
                   which it is not naturally found allows the DNA to be expressed in a greater variety                                
                   of cells and in greater quantities than found in nature.  Recombinant DNA is the                                   
                   basis of the entire biotechnology industry.  Thus, recombinant DNA comprising a                                    
                   particular DNA sequence is not patentably distinct from the DNA sequence itself.                                   
                           Similarly, instant claim 10 is directed to an expression vector that is a                                  
                   recombinant plasmid.  This claimed product is an obvious species of the                                            
                   “expression vector” recited in the ‘558 patent’s claim 6.  Expression vectors are                                  
                   either plasmids or viruses; since a plasmid is one of only two options, a plasmid                                  
                   expression vector is not patentably distinct from a generic expression vector.                                     
                           In addition, instant claim 7 is generic to the ‘558 patent’s claim 3.  That is,                            
                   claim 7’s recitation of the “DNA sequence encoding a Trichoplusia ni IIM protein”                                  
                   encompasses the ‘558 patent’s sequences comprising SEQ ID NO’s 1 or 2, as                                          
                   well as sequences encoding SEQ ID NO’s 3 and 4.  “[A] later genus claim                                            
                   limitation is anticipated by, and therefore not patentably distinct from, an earlier                               
                   species claim.”  Eli Lilly & Co. v. Barr Labs., Inc., 251 F.3d 955, 971, 58 USPQ2d                                 
                   1869, 1880 (Fed. Cir. 2001).                                                                                       














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