Interference No. 103,675
Chen included the results in his report to Dr. Vyas (CX 34).
In January 1991, Dr. Chen allegedly prepared a second sample
of the compound known as BMS-46546 as allegedly shown in Dr. Chen's
laboratory notebook number 30449 at page 016 (CX 29). The experiment
on said notebook page was started on January 1, 1991 and completed on
February 1, 1991. According to Dr. Chen's notebook page, 29 milligrams
"pdt." in 85% yield was obtained. The product is defined only as "C7-F
Taxol." Under the heading "WITNESSED" at the bottom left hand side of
the page an illegible signature is found along with a date which
appears to be October 2, 1995, more than 4 (four) years after the
experiment had been completed. No person who "witnessed" the notebook
has testified in this proceeding.
Chen et al. allege that Drs. Chen and Farina submitted 45
milligrams of said sample, 16 milligrams more sample than prepared on
February 1, 1991, to the Compound Control Department on January 15,
1991, before February 1, 1991, the alleged date on which Dr. Chen
completed the experiment preparing said compound. Dr. Chen filled out
a compound submission form indicating, inter alia: the date submitted
(January 15, 1991); the batch number (30449-016); a proposed empirical
formula; a molecular weight; the amount of sample; a proposed
structural formula; and, a proposed utility (Antitumor Agent). The
compounds were tested in vivo for antitumor activity and by not later
106
Page: Previous 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 Next
Last modified: November 3, 2007