Interference No. 103,675
Taxotere12 side-chain to the 7-fluoro epimer baccatin III derivatives
he earlier prepared. Dr. Kant allegedly prepared the compounds in
November 1991 and recorded them in his laboratory notebook number
32108 (CX 38; CX 39). Dr. Kant understood that he had prepared 7-
fluoro derivatives of the baccatin III derivatives earlier prepared by
Dr. Chen based on the information provided to him by Dr. Chen (CR
2141-42, 2162, 2175, 2181, 2191, 2193; CX 40).
Thus, CX 37 is directed to compounds not within any of the
counts. Moreover, at the time the compounds shown therein were
synthesized Drs. Chen and Farina believed the compounds to be mixed
fluorine epimers of taxol. Similarly, CX 38 and 39 represent mixed
fluoro baccatin compounds not compounds within any of the counts.
In August 1992, Dr. Chen alleges that he prepared 7-deoxy-8-
desmethyl-7,8-cyclopropyl baccatin III by the procedure outlined in
his laboratory notebook number 33450 (CX 87). Dr. Chen's notebook was
signed by Marc A. Bruce, a person who has not testified in this
proceeding, on November 24, 1992, next to the caption "WITNESSED AND
UNDERSTOOD BY:". The notebook indicates that Dr. Chen began with 30
milligrams of starting reactant; 15 milligrams of tetrabutyl ammonium
borohydride and 1 milliliter of dichloro methane. In late August 1992,
12 Taxotere is the tradename for the Rhone-Poulenc Rorer Taxol
analog bearing a different side-chain than Taxol. CR62.
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