NICHOLS et al. V. TABAKOFF et al. - Page 19





               Interference No. 104,522 Paper108                                                                                           
               Nichols v. Tabakoff Page 19                                                                                                 
               37. Mr. Ezell further testified that proton NMR spectrum, by itself, does not provide                                       

               enough data to assign a chemical structure to a compound, i.e., additional analytical                                       
               data was needed (NR, p. 208,11. 13-21).                                                                                     
               38. The third page of Ex 2032 (apparently dated "5/18") contains an entry reading                                           

               got good carbon NMR." No copy of the noted carbon NMR (authenticated or not) is of                                          
               record.                                                                                                                     

               39. The last line of the third page of Ex 2032 is illegible.                                                                
               40. Dr. Nichols testified that the last line reads "8/2/92 No NIH activity." Dr. Nichols                                    

               further testified that the date is a mistake, i.e., it should have been "8/2/94." [NR, p. 98,                               

               1. 8 - p. 99,1. 16.]                                                                                                        

               41. Although there is no apparent notation in Ex 2032 documenting sending 250 mg                                            
               of sample 94A-85-1 to NIH for testing, Dr. Nichols testified that such a sample was sent                                    

               on May 13, 1994 (NR, p. 31, T 30).                                                                                          
               42. James P. Stables, Program Director for the NIH Anticonvulsant Project, testified                                        

                       Exhibit A is a copy of an Antiepileptic Drug Development (ADD)                                                      
                       Registration Record (2 pages) that was received from Dr. Al Nichols and                                             
                       processed by NIH on June 1, 1994. The ADD Registration Record is for                                                
                       the compound identified as 94A-85-1 by Dr. Nichols and assigned                                                     
                       identification number ADD 234001 by NIK The ADD Registration Record                                                 
                       includes a structural drawing of the compound as provided by Dr. Nichols.                                           
                       [Ex 2035, 1% 2-3].'                                                                                                 
                       Exhibit A appears identical to Ex 2036.                                                                             


                       7 Citation to the direct testimony of Mr. James P. Stables are to Ex 2035 since various exhibits                    
               referred to by Mr. Stables are attached thereto. However, citations to cross-examination of Mr. Stables                     
               are to Nichols Record ("NR") pages because Nichols did not submit the "Cross-Examination                                    
               Interrogatories to James P. Stables" as a separate exhibit. We note that NIR pp. 214-216 correspond to                      
               Ex 2035 sans attached exhibits.                                                                                             







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