Appeal No. 2003-1417 Page 3
Application No. 09/298,404
different pathways can be modulated by the presence or absence of signals
generated by other receptors. . . . Adaptor molecules may be critical in
integrating multiple signaling cascades and in determining the cell type specific
response to extracellular stimuli.” Specification, page 1.
The specification discloses the cloning and characterization of three
human cDNAs encoding putative adaptor proteins designated Nsp1, Nsp2, and
Nsp3. The amino acid sequences of the Nsp1, Nsp2, and Nsp3 proteins are
shown in the specification’s SEQ ID NOs 1, 3, and 5, respectively. The
specification discloses that “[s]everal characteristics suggest that Nsp1 could
play an important role in modulating the response to external stimuli.” Page 30.
One such characteristic is that epidermal growth factor (EGF) “induced a rapid
tyrosine phosphorylation of Nsp1 (SEQ ID NO:1).” Page 60.
Among the related products disclosed in the specification are antibodies
that bind to the Nsp1, Nsp2, or Nsp3 proteins. See, e.g., pages 4-5 and 41-49.
Such antibodies are disclosed to be “promising drug candidates” for inhibiting the
production or activity of Nsp1, Nsp2, or Nsp3. See page 41.
Discussion
Claims 60, 61, and 62 are directed to “[a]n antibody which specifically
binds to” Nsp1, Nsp2, or Nsp3, respectively. The remaining claims depend on
one or more of claims 60, 61, or 62.
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