Ex Parte Douin et al - Page 4


              Appeal No. 2004-0378                                                                                            
              Application No. 09/765,675                                                                                      

              Id., page 2.  “It is known to use, as thickeners for aqueous media, water-soluble or                            
              water-dispersible polymers . . . such as carbopol, wherein said polymers can have a                             
              long chain length and a high molecular weight.  When such polymers are used in                                  
              compositions in the form of nanoemulsions, some of such nanoemulsions may tend to                               
              exhibit a decrease in at least one characteristic, such as stability and transparency.”  Id.                    
                      The specification discloses that “oil-in-water nanoemulsions comprising oil                             
              globules with an average size of less than 150nm comprising at least one oil and at                             
              least one amphiphil[i]c lipid can be thickened with at least one cationic polymer.”  Page                       
              3.  In a working example, the specification reports that an oil-in-water nanoemulsion                           
              containing a cationic polymer (quaternized (C8-C30)alkylhydroxyethylcellulose, a.k.a.                           
              Quatrisoft LM 200) was stable on storage for two months at room temperature and at                              
              45°C, and had a turbidity of 375 NTU and a viscosity of 650 mPa.s.  See page 50.  By                            
              contrast, “[i]f the Quatrisoft LM 200 is replaced with the same amount of Carbopol                              
              Ultrez, a composition which is not thickened, not transparent (turbidity > 1000 NTU) and                        
              not stable on storage is obtained.”  Page 51.                                                                   
                                                         Discussion                                                           
                      Appellants have grouped the claims subject to each rejection together, with the                         
              exception of claims 78-82, which are argued separately from the other claims rejected                           
              over Restle and Ziegler.  See the Appeal Brief, page 6.  We will consider claims 1, 20,                         
              23, 64, and 78 as representative of the rejected claims.  37 CFR § 1.192(c)(7).                                 
                      Claim 1 is directed to an oil-in-water nanoemulsion (i.e., an emulsion in which the                     
              oil globules have an average size of less than 150 nm), comprising an oil, an                                   
              amphiphilic lipid, and a “cationic polymer comprising at least one hydrophobic block and                        





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