Ex Parte Tsuji et al - Page 5


                  Appeal No.  2005-0543                                                           Page 5                    
                  Application No.  09/992,221                                                                               

                  from the prior art.  In making this evaluation, all facts must be considered.  The                        
                  Patent Office has the initial duty of supplying the factual basis for its rejection.  It                  
                  may not, because it may doubt that the invention is patentable, resort to                                 
                  speculation, unfounded assumptions or hindsight reconstruction to supply                                  
                  deficiencies in its factual basis.  To the extent the Patent Office rulings are so                        
                  supported, there is no basis for resolving doubts against their correctness.                              
                  Likewise, we may not resolve doubts in favor of the Patent Office determination                           
                  when there are deficiencies in the record as to the necessary factual bases                               
                  supporting its legal conclusion of obviousness.”  In re Warner, 379 F.2d 1011,                            
                  1017, 154 USPQ 173, 178 (CCPA 1967), cert. denied, 389 U.S. 1057 (1968)                                   
                  (emphases in original).                                                                                   
                         The examiner, in the final rejection, stated that the fluorescent method of                        
                  Inami, as well as Kim, Hansen and Hoffman was a “functional equivalent” of the                            
                  absorbance method of Bentley.  See Final Rejection mailed December 24, 2003.                              
                  In the Examiner’s Answer, however, the examiner states that                                               
                         Bentley is not cited for its use of any particular analytical technique                            
                         per se.  Rather, Bentley is cited for the fact that one practicing the                             
                         cited art methods of cell counting and classification, such as                                     
                         disclosed by Inami [ ], would have recognized the desirability of                                  
                         classifying the lipid particles so as to ensure an accurate count of                               
                         the total amount of cells present in the sample, as well as an                                     
                         accurate count of the various cell types therein.  Thus, even                                      
                         assuming the techniques of Bentley would not have been                                             
                         considered equivalent to those of Inami and the other patents, the                                 
                         artisan of ordinary skill would nevertheless have recognized from                                  
                         Bentley the importance of classifying lipid particles in a marrow                                  
                         analysis, so as to ensure an accurate cell count, precisely as                                     
                         recited in appellants’ claims.                                                                     
                  Examiner’s Answer, page 9.                                                                                





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