Appeal No. 2006-0227 Page 8
Application No. 10/121,264
As described by Chu, these figures show:
A chip or tray 400 designed to allow the analysis of all 24 chromosomes
on a single slide 70 . . . . The tray 400 is one which can snap on to or
otherwise be attached to a microscope slide 70. The chip or tray 400
contains 8 wells 410 with each well 410 separated from neighboring wells
410 by a gap or a trough 420. Such a tray 400 is illustrated in FIG. 16A.
Col. 32, lines 57-63. “FIG. 16B is a side view of the 8 well tray 400 shown in FIG. 16A.”
Col. 10, lines 14-15. “In a preferred embodiment, the probes are predried onto the 8
wells 410 of the tray 400 with probes for 3 different chromosomes in each well 410. . . .
Metaphase or interphase cells are fixed across a slide 70 and the slide 70 is placed in
contact with the tray 400. Then buffer is added to the openings 430 to each well 410.”
Col. 33, lines 18-24.
Chu also describes a “more preferred embodiment [in which] the slide 70
includes positive and negative controls in the regions 440 which are those which are in
contact with the hybridization fluid in each of the 8 wells 410. Using microarray
technology . . . , nucleic acids which are complementary to the probes being used to
paint the chromosomes are coated and immobilized onto the slide 70 . . . . One example
of an array is shown in FIG. 16E in which all 24 nucleic acids are arrayed around the
edges of each region 440 which will contact each of the 8 wells 410.” Col. 33, lines 46-
60.
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