Appeal No. 2006-0227 Page 9
Application No. 10/121,264
Chu’s Figure 16E is reproduced below:
The figure shows one of the regions 440 having twenty-four smaller regions
around its perimeter; the smaller regions are labeled with the numbers 1 through 22, x,
and y, corresponding to the twenty-four chromosomes in the human genome. Chu
describes the function of the smaller regions as follows: “If[,] for example, a first region
440 is one which will contact a well 410 containing probes for chromosomes 1, 2 and 3,
then the control nucleic acids for these chromosomes should light up after staining
(each showing only a single color) while the remaining 21 controls should not hybridize
and should not fluoresce. In this manner there are both positive and negative controls
and labels for each of the 8 wells 410.” Col. 33, lines 60-67.
Thus, as we interpret the reference disclosure, Chu teaches a microscope slide
to allow chromosome painting of all twenty-four human chromosomes on a single slide.
In a preferred embodiment, each of eight regions on the slide has samples of each of
the twenty-four human chromosomes (1-22, X, and Y) arrayed around its edge; the
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