Appeal 2006-0592
Application 10/278,274
REFERENCES
The Examiner relies on the following references:
Earhart US 6,300,137 B1 Oct. 9, 2001
Lowe US 2002/0081597 A1 Jun. 27, 2002
Perbost US 6,171,797 B1 Jan. 9, 2001
OBVIOUSNESS
The examiner rejected claims 1-12, 14-18, and 20 under 35 U.S.C.
§ 103(a) as unpatentable over Earhart, Lowe, and Perbost.
The Examiner’s Answer refers to the Office Action mailed September
27, 2004 (Office Action) for the factual findings supporting the rejection of
record. According to the Examiner, Earhart describes a method of
producing an array of at least two different nucleic acid ligands, covalently
bonded to the surface of a substrate, wherein Earhart’s method comprises, in
pertinent part:
• Providing a substrate having a surface displaying hydroxyl
groups (Earhart Col. 4, ll. 25-32; Figs. 2 and 4A). According to
the Examiner, this meets step (a) of the claimed method (Office
Action 8).
• Contacting the substrate with DMT-blocked reactive nucleoside
monomers (i.e., monomers blocked at the 5’ end with a labile
blocking group) to allow them to covalently bond to a plurality
of areas on the substrate (Earhart Col. 4, ll. 25-32; Col. 6, ll. 31-
35; Figs. 4A and 4B). According to the Examiner, this meets
step (b) of the claimed method (Office Action 8).
• Contacting the blocked nucleoside monomers on the substrate
with an oxidation solution (Earhart Col. 7, ll. 1-4; Claim 10).
According to the Examiner, this meets step (c) of the claimed
method (Office Action 8).
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