Ex Parte Esser et al - Page 28


                Appeal 2006-3252                                                                                 
                Application 09/536,728                                                                           

           1    "second" or umpteenth" selection.  The Examiner did not have to have a                           
           2    reason for "first" selecting the compound of Example 14 because Olson                            
           3    explicitly tells one that the compound is useful for Olson's purpose.                            
           4           The question then becomes, why modify the compound of                                     
           5    Example 14 to account for differences between that compound and, e.g., the                       
           6    compound of Esser claim 23.  There are not a "large number of variables"                         
           7    involved.  The only "variable" (difference would be a better word) is the                        
           8    ethyl groups on the nitrogen of the Example 14 compound (Formula 6).  The                        
           9    relevant question is:  Would one having ordinary skill in the art have found                     
          10    it obvious to replace those ethyl groups with methyl groups to "come up"                         
          11    with the compound of Esser claim 23 (Formula 2) for use in the process of                        
          12    Olson.  The answer is "yes."  Why?  Olson tells us in no uncertain terms that                    
          13    the groups which can be attached to the nitrogen are hydrogen and 1-3 alkyl                      
          14    (which means methyl, ethyl, propyl and iso-propyl, or a total of five                            
          15    choices).  The KSR reason for changing ethyl to methyl is provided right in                      
          16    the prior art and it manifestly would have been "obvious to try" (in the KSR                     
          17    sense, 127 S. Ct. 1742, col. 2) hydrogen, methyl, propyl or isopropyl in                         
          18    place of ethyl.  Section 103 allows one skilled in the art to do so and Esser is                 
          19    not entitled to a claim which preclude one skilled from doing so.                                
          20           The panel made the following observation on page 7 of its opinion:                        
          21    "there is no evidence that the claimed compounds are homologs or that they                       
          22    have the same properties as the prior art [Olson] compounds."  At pages 7-8                      
          23    of the opinion, the panel also said there was no expectation that Esser                          
          24    compound (Formula 2) and the Olson compound (Formula 6) would have                               
          25    similar properties.  The Olson ethyl compound (Formula 6) and the Esser                          

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