Ex Parte 5073484 et al - Page 6

                Appeal 2007-0725                                                                                
                Reexamination Control 90/006,785                                                                
                Patent 5,073,484                                                                                
                6. An  acidic  indicator  material,  e.g., a  dye  such  as  fluorescein,  is                   
                physically adsorbed onto the immunological counterpart.  (Weiss at 1:55-                        
                58).                                                                                            
                7. If  the  sample  contains  the  material  to  be  detected,  the  “indicator                 
                material will either be released from the particle or will become affixed                       
                thereto  through  chemical  action”  depending  upon  the  immunological                        
                counterpart used.  (Weiss at 1:58-62).                                                          
                8. Weiss  states  that  “[t]he  immunological  reaction  provides  a  definite                  
                visual effect which can be easily observed.”  (Weiss at 4:66-67).                               
                9. Regarding Weiss, Patentee provides testimony from Dr. Julian Gordon,                         
                who identifies himself as a “Senior Research Fellow in the Volwiler Society                     
                at Abbott Laboratories [an exclusive licensee of the ‘484 patent], and also a                   
                licensing manager.”  (Gordon’s Declaration at ¶1).                                              
                10.   Dr.  Gordon  states  that  “Weiss does  not  disclose  labeling  with  a                  
                chemical  moiety  as  called  for  in claim  23”  since  the  association  by                   
                absorption is “transient.”  (Gordon’s  Declaration at ¶ 5).                                     
                11.   Dr. Gordon states that he “seriously doubt[s] that the Weiss assay                        
                would actually work.”  (Gordon’s Declaration at ¶ 6).                                           
                12.   Dr. Gordon testifies that he “has never seen one in use in all [his]                      
                years working in the field.”  (Gordon’s Declaration at ¶ 6).                                    
                13.   Dr. Gordon states that he “conducted a search of U.S. patents that                        
                include Weiss as a cited reference” and that “[n]one of these patents make                      
                use of an adsorbed dye that in use can be disassociated from its ligand or                      
                anti-ligand.” (Gordon’s Declaration at ¶ 7).                                                    



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