Ex Parte Chen et al - Page 9

                  Appeal 2007-1073                                                                                           
                  Application 10/308,176                                                                                     

                         “The test for obviousness is what the combined teachings of the                                     
                  references would have suggested to one of ordinary skill in the art.”  In re                               
                  Young, 927 F.2d 588, 591, 18 USPQ2d 1089, 1091 (Fed. Cir. 1991).                                           
                  However, “before a conclusion of obviousness may be made based on a                                        
                  combination of references, there must have been a reason, suggestion, or                                   
                  motivation to lead an inventor to combine those references.”  Pro-Mold and                                 
                  Tool Co. v. Great Lakes Plastics Inc., 75 F.3d 1568, 1573, 37 USPQ2d                                       
                  1626, 1629 (Fed. Cir. 1996).  “[E]vidence of a motivation to combine                                       
                  [references] need not be found in the prior art references themselves, but                                 
                  rather may be found in ‘the knowledge of one of ordinary skill in the art or,                              
                  in some cases, from the nature of the problem to be solved.’”  Dystar                                      
                  Textilfarben Gmbh v. C.H. Patrick Co., 464 F.3d 1356, 1366, 80 USPQ2d                                      
                  1641, 1649 (Fed. Cir. 2006) (emphasis in original, quoting In re Dembiczak,                                
                  175 F.3d 994, 999, 50 USPQ2d 1614, 1617 (Fed. Cir. 1999)).                                                 
                         In the present case, we do not find that the Examiner has provided                                  
                  evidence of a sufficient reason, suggestion or motivation to combine the                                   
                  cited references arising either from the prior art, from the nature of the                                 
                  problem solved, or from the knowledge of one of ordinary skill in the art.                                 
                  We particularly find no teaching in Barbier or Chen that would have led one                                
                  of ordinary skill in the art to substitute a small amount of tocopherol                                    
                  antioxidant with a large amount of TPGS surfactant, as claimed.  Nor do we                                 
                  find motivation to replace the polyethylene glycol emulsifier described in                                 
                  Barbier with tocopherol PEG-1000 succinate surfactant as taught by Chen,                                   
                  or an indication that one of ordinary skill in the art would have been led to                              



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