Appeal 2007-1624
Application 10/424,662
76. An array of oligonucleotides comprising oligonucleotides of
differing sequences, wherein said differing oligonucleotides are
attached to different particles arranged on a defined area of a
substrate in a planar configuration, said particles being encoded
with a chemical or physical characteristic that allows
identification of the oligonucleotide attached thereto, and
wherein said particles are permanently anchored to said
substrate.
77. An array of oligonucleotides and a contiguous aliquot of
solution containing analytes in contact said array, said array
comprising oligonucleotides of differing sequences, wherein
said differing oligonucleotides are attached to different particles
wherein said particles are encoded with a chemical or physical
characteristic that allows identification of the oligonucleotides
attached thereto, wherein said particles are arranged on a
substrate in a planar, spatially nonrandom but compositionally
random configuration, and said aliquot is placed on said planar
configuration.
90. An array of oligonucleotides prepared by a method
comprising the following steps:
providing a multiplicity of reservoirs arranged in a
predetermined layout, wherein each of said reservoirs has a
known position within the layout and contains a plurality of
different types of particles having a different oligonucleotides
attached thereto and each of said particle types being encoded
with a chemical or physical characteristic that uniquely
identifies said particle type and oligonucleotide attached
thereto, and wherein the known positions of the reservoirs
within the layout in combination with the encoding indicate the
types of particles contained therein; and transferring said
suspensions of particles from the reservoirs onto a substrate in a
layout preserving manner and forming a multiplicity of planar
particle arrays on said substrate, such that the particle types of
each particle array are identical to the particle types of the
corresponding reservoir and the position of each of the particle
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