Appeal 2007-2955
Application 10/190,425
16. “[M]odification of wells with specific cell-binding molecules permits
selective binding of cells to specific wells” (Taylor, col. 12, ll. 1-4), and
“allows one well, a group of wells or the entire array to specifically
‘recognize’, grow and screen cells from a mixed population of cells” (id.
at 12, ll. 9-12).
17. Taylor’s “cell recognition” or “cell-binding” molecules include
antibodies, lectins, and extracellular matrix proteins (Taylor, col. 13, ll.
25-28), and Taylor’s “base” “can be a glass, plastic, or silicon wafer, such
as a . . . coverslip” (id. at col. 8, ll. 37-39).
18. “The density of cells attached to the wells is controlled by the cell
density in the cell suspension, the time permitted for cell attachment . . .
and/or the density of cell binding molecules in the wells” (Taylor, col. 12, ll.
24-27).
19. Taylor differs from the claimed invention in that the cell-recognition
molecules (i.e., probes) are bound to hydrophilic spots on an otherwise
hydrophobic base (i.e., solid support), rather than being “deposited as spots
on the surface of a hydrated gel coated solid support,” as required by instant
claim 1.
Wagner
20. Wagner is directed to “an array of protein-capture agents comprising:
a substrate; at least one organic thinfilm covering some or all of the surface
of the substrate; and a plurality of patches arranged in discrete, known
regions on the portions of the substrate surface covered by organic thinfilm,
wherein (i) each patch comprises protein-capture agents immobilized on the
organic thinfilm, where the protein-capture agents of a given patch are
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