Ex parte A. SAID EL SHAMI et al. - Page 3




          Appeal No. 93-3369                                                          
          Application 07/344,179                                                      


               Claims 70-90 are rejected under 35 U.S.C.  103 over Diamond           
          in combination with Liotta.                                                 
               Claims 70-90 are rejected under 35 U.S.C.  103 over                   
          Diekmann in combination with Liotta.                                        
               Claims 70-90 are rejected under 35 U.S.C.  103 over Graas             
          in combination with Liotta.                                                 
                                     Background                                       
               Various diagnostic devices for determining the presence or             
          absence of a particular molecule of interest in a sample had been           
          developed prior to the filing date of this invention.  These                
          devices had been used to detect various molecules of interest,              
          including drug residues and specific hormones in urine samples              
          and in blood samples.  The detection materials associated with              
          diagnostic devices, their specific design and their mode of                 
          action varied as well.                                                      
               The use of immobilized materials which specifically bind to            
          a particular molecule of interest, and thus separate it from a              
          sample, was known in the art prior to the filing date of this               
          application.  Also known, were techniques for labeling                      
          immobilized materials involved in the specific binding required             
          for                                                                         



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