Appeal No. 93-3369
Application 07/344,179
be displaced from the antibody by analyte in a sample but will
remain bound to the antibody in the absence of analyte in the
sample. Pages
14-17 of the specification set forth reaction and affinity
constant equations that are required for selecting an “analyte
label” molecule such that displacement of “analyte label” by any
analyte that is in a sample will occur. See the examples of
“analyte label” selection on pages 19-33 of the specification.
Discussion
The Examiner presents three rejections under 35 U.S.C.
§ 103, each of which involves the teachings of Liotta. The three
references, Diamond, Diekmann and Graas, are each used in
combination with Liotta, each one being set forth in a separate
rejection. Liotta teaches a test strip and its use in
antibody/antigen screening assays. The test strip contains a
reaction zone and a display zone for indicating the presence of a
labeled molecule.
The first rejection is premised on the following: Diamond
teaches a DNA hybridization assay involving DNA probe materials
that have been immobilized on a solid support with a labeled
polynucleotide bound to the DNA probe material. The labeled
polynucleotide is removed upon hybridization between the DNA
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