Appeal No. 93-3369
Application 07/344,179
of the column in the microfuge tube opening in order to
collect the eluate.
Diamond does not teach the use of antibodies and analytes
and does not use a second solid phase support to absorb the
removed labeled polynucleotide. Liotta is relied upon to supply
these elements. The device of Liotta involves antibodies and
analytes. In Liotta the analytes are referred to as antigens.
The layered device of Liotta has two reaction zones on the same
solid support, the latter of which provides means for detecting a
labeled antibody or labeled antigen via a visible color.
The Examiner concludes that it would have been obvious to a
person having ordinary skill in the art at the time of the
invention to substitute the bound antibody-labeled antigen
complex of Liotta for the polynucleotide complex of Diamond in
the bead-packed column of Diamond, because the separations
involved are analogous, and to provide a second solid support.
For a more detailed discussion, we make reference to pages 4 and
5 of the Examiner’s Answer.
The two additional rejections are similar in that both
Diekmann and Graas disclose devices designed for use in
centrifugation which are of a column and sleeve type assembly,
with a reaction taking place on a solid support in the column.
Each of these references provides a generic reference to use in
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