Ex parte CARTER et al. - Page 3




          Appeal No. 95-4493                                                          
          Application 07/756,646                                                      


          OPINION                                                                     
               A.  The Rejection under 35 U.S.C. § 103                                
               The claimed antibiotic compound LL-E19020 alpha (hereafter             
                                                              1                       
          “alpha-1") is the C-21 epimer of the known antibiotic LL-E19020             
          alpha (hereafter “alpha”).  Alpha-1 is prepared by the process              
          set forth on pages 10-13 of the specification.                              
               Carter II describes the discovery of antibiotic alpha and              
          its preparation on page 1511.                                               
               From the properties recited for alpha in the Carter II                 
          article and those properties of alpha-1 recited in appealed claim           
          1, it is apparent that the examiner and appellants agree that               
          alpha and alpha-1 are different compounds but have the same                 
          structural formula.  As stated by the examiner, the “sole                   
          difference” between the prior art and the claimed compound “lies            
          in the configuration of the trisaccharide moiety at the C-21                
          position” (answer, page 4).                                                 
               The examiner concludes that the claimed compound “is                   
          rendered obvious” because the prior art compound is “structurally           
          similar” and both “possess similar antibacterial properties”                
          (answer, page 4).  The examiner states that “the courts have                
          consistently held that if the claimed invention is structurally             


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