Ex parte CARTER et al. - Page 7




          Appeal No. 95-4493                                                          
          Application 07/756,646                                                      


               Appellants' response to this new ground of rejection is that           
          the law is clear that for a rejection based upon inherency to be            
          sustained, the inherency must be an inevitable result and not               
          merely a probability or possibility (reply brief, paragraph                 
          bridging pages 2-3).  Appellants argue that the presently claimed           
          alpha-1 material was not recognized or identified in Carter.                
          Thus it is not certain or inevitable that alpha-1 was present in            
          the fermentation materials produced in Carter and a rejection               
          based upon inherency is not proper (reply brief, page 3).                   
               For a reference to anticipate a claim, “the disclosure need            
          not be express, but may anticipate by inherency where it would be           
          appreciated by one of ordinary skill in the art.”  Glaxo Inc. v.            
          Novopharm Ltd., 52 F.3d 1043, 1047, 34 USPQ2d 1565, 1567 (Fed.              
          Cir. 1995), cert. denied, 116 S. Ct. 516 (1995).  As correctly              
          stated by appellants, the inherency must be an inevitable result            
          and not merely a possibility.  See In re Oelrich, 666 F.2d 578,             
          581-82, 212 USPQ 323, 326 (CCPA 1981).                                      
               The process of preparing compounds alpha and beta of Carter            
          is markedly different than the process of preparing alpha-1                 
          disclosed by appellants (as specifically set forth on pages 10-13           
          of the specification).  Appellants' process does not use a silica           
          column purification as set forth by Carter at column 8, lines 31-           

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