Appeal No. 95-0865
Application 08/08/007,950
Bisacchi describes deprotection by treatment with sodium
methoxide in methanol (col. 8, lines 44-50), particularly when
the "Prot" group is benzoyl, as required by Claim 21. Slusarchyk
reveals that conversion of a chloro group at the 6-position to an
alkoxy group ()O)R in Slusarchyk) can be accomplished by known
4
methods (page 9, last line through page 10, line 22).
Hagberg I describes hydrolysis of Compound III (page 9)
1 2 2
containing an X group which can be, inter alia, ) OR , where R ,
inter alia, may be alkyl (e.g., methyl), in the presence of
sodium hydroxide (page 9, line 27) to produce a "compound of the
[Hagberg I invention" which, of course, is a purine compound with
an oxo (4O) at the 6-position (page 7, Compound I).
r. Claim 22--prior art rejection
Claim 22 is rejected as being unpatentable over Bisacchi,
Slusarchyk, Searcey, Hagberg I, Ichikawa and Zahler. Claim 22 is
narrower than Claim 6 in that it limits the "Prot" group to acyl.
Claim 22 also requires a step (b) and a step (c).
Step (b) calls for (indentation and paragraph numbers
added):
(1) treating the product from part (sic--step) (a)
with hot aqueous sodium or potassium hydroxide or
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