Appeal No. 95-0865
Application 08/08/007,950
the use of an R protecting group which is benzoyl (col. 3, line4
62, corresponding to applicants' Prot group; (2) the leaving
group triflyl (col. 3, line 67), corresponding to applicants' X;
and (3) 2-amino-6-chloropurine (col. 7, last line), which
corresponds to applicants' Y being chloro. As previously noted,
1
both Searcey and Hagberg I describe the use of tetrabutylammonium
salt forms corresponding to applicants' R through R being n-1 4
butyl.
i. Claim 12
Claim 12 is rejected as being unpatentable over Bisacchi,
Slusarchyk, Searcey, Hagberg I, Ichikawa and Zahler.
Claim 12 is believed to be unpatentable for the same
reasons that Claims 6-9 and 11 are unpatentable, it being noted
that Bisacchi describes the use of a leaving group X which can be
p-nitrobenzenesulfonyloxy (nosyl) (col. 4, lines 30-31).
j. Claim 13
Claim 13 is rejected as being unpatentable over Bisacchi,
Slusarchyk, Searcey, Hagberg I, Ichikawa and Zahler. Claim 13
requires two additional steps.
Step (b) involves treatment to remove the "Prot" protecting
groups and replacement of those groups with hydrogen () H) groups.
The reaction is shown schematically below:
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