Appeal No. 95-0865
Application 08/08/007,950
The reason we reversed the examiner's rejection of claim 6
based on Bisacchi, Slusarchyk and Searcey was the absence of any
teaching in Searcey that the use of the tetraalkylammonium salt
form would serve in reactions with compounds beyond those
containing a halo group. The deficiency we found in the
examiner's rejection, however, is cured by a reference already in
the record, namely, Hagberg I, Ichikawa and Zahler. Whereas
Searcey reacts an imidazole in the tetraalkylammonium salt form
with a compound containing a halo group, Hagberg I teaches
reaction of a purine in the tetraalkylammonium salt form with a
compound containing mesyl group. See Example 10 of Hagberg I
(page 33). Furthermore, Hagberg I teaches that the "leaving"
group X (see Compound XIII, page 16) can be chloro, bromo, iodo2
or )SO R (page 13, lines 18-19) where R can be (page 9,2 2 2
lines 21-24):
(1) alkyl containing 1-8 carbon atoms (e.g.,
mesyl);
(2) fluorinated alkyl containing 1-8 carbon
atoms, such as trifluoromethyl (triflyl);
(3) alkylaryl such as benzyl, or
(4) aryl such as unsubstituted for substituted
phenyl.
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