Appeal No. 95-0865
Application 08/08/007,950
use of purines in their alkali salt forms. We also note that
Slusarchyk describes the use of only the 3-monosubstituted
cyclobutanes. See Compound 2 (page 5). The Slusarchyk leaving
group X is described as being selected from the group consisting
of chloro, bromo, iodo, an aryl sulfonate (e.g.,
p-toluenesulfonyloxy) or an alkyl sulfonate (e.g.,
methanesulfonyloxy (mesyl)) (page 5, lines 20-21).
Searcey describes the reaction of nitro-imidazoles with halo
containing compounds and indicates that better yields are
obtained when the nitro-imidazole is reacted in its
tetraalkylammonium salt form than when reacted in its alkali salt
form. To be sure, an imidazole is not the same as a purine.
However, the similarities between Searcey's imidazole and
Slusarchyk's purines are apparent upon review of their respective
structures:
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