Ex parte SINGH et al. - Page 19




          Appeal No. 95-0865                                                           
          Application 08/08/007,950                                                    

                    (1) a perfluoroalkane sulfonyloxy group,                           
                    (2) a nitro-substituted benzene sulfonyloxy group, or              
                    (3) a fluorosylfonyloxy.                                           
          Bisacchi and Slusarchyk describe reaction of a purine in its                 
          alkali salt form and a cyclobutane.  Neither describes the use of            
          a purine in its tetraalkylammonium salt form.                                
               Searcey describes the reaction of an imidazole in its                   
          tetraalkylammonium salt form with compounds having leaving groups            
          which are halo groups.                                                       
               The difficulty with the examiner's position is that there is            
          nothing in Searcey which would suggest that the imidazole in its             
          tetraalkylammonium salt form would also react with compounds                 
          having leaving groups X called for by the claims.  There is no               
          teaching in the combination of Bisacchi, Slusarchyk, and Searcey             
          which would show any interchangeability between the use of                   
          purines in their alkali salt forms with purines in their                     
          tetraalkylammonium salt forms.  Thus, without something more,  we2              
          regard the examiner's rejection to have been based on                        
          impermissible hindsight.  Compare In re McLaughlin, 443 F.2d                 
          1392, 1395, 170 USPQ 209, 212 (CCPA 1971).                                   



             As will become apparent, infra, we found that "something more" in the2                                                                        
          teachings of Hagberg I, Ichikawa and Zahler.                                 
                                        - 19 -                                         





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