Appeal No. 95-0865
Application 08/08/007,950
where:
P is a protecting group, e.g., acyl (page 5, line 20) and
X is a leaving group, e.g., chloro, bromo, iodo or an aryl
group (e.g., p-toluenesulfonyloxy) or an alkyl group (e.g.,
methanesulfonyloxy) (page 5, lines 20-21).
23. The reaction of Slusarchyk Compound 2 with
Slusarchyk Compound 14 is carried out in the presence of a base,
such as potassium carbonate, sodium hydride or potassium hydride
(page 5, line 43).
24. Significant disclosure found in Slusarchyk, but
not found in Bisacchi, is that the leaving group X of Slusarchyk
Compound 2 is described as including halo groups (chloro, bromo,
iodo) whereas the corresponding X group of Bisacchi Compound 13
is not described as including halo groups (col. 3, lines 64
through col. 4, line 31; col. 7, lines 44-48).
Hagberg I European Patent Application 0 055 239
25. Hagberg I describes various organic synthesis
techniques. One technique of interest is Method of Preparation L
which begins on the last line of page 15 and continues to line 17
on page 16.
26. Method L is described as involving a reaction of a
Compound XII, which is said to have the formula:
- 13 -
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